NOX4 expression and distal arteriolar remodeling correlate with pulmonary hypertension in COPD.

Xiaotong GuoYuchun FanJieda CuiBinwei HaoLi ZhuXiao SunJinxi HeJiali YangJianda DongYanyang WangXiao-Ming LiuJuan Chen

Published in: BMC pulmonary medicine (2018)

These results suggest that the NOX4-derived ROS production may play a key role in the development of PH in COPD by promoting distal pulmonary vascular remodeling.

Keyphrases

pulmonary hypertension
chronic obstructive pulmonary disease
reactive oxygen species
lung function
pulmonary artery
minimally invasive
poor prognosis
pulmonary arterial hypertension
dna damage
binding protein
cystic fibrosis
oxidative stress