Cognitive functioning and lifetime major depressive disorder in UK Biobank.
Laura de NooijMathew A HarrisMark James AdamsToni-Kim ClarkeXueyi ShenSimon R CoxAndrew M McIntoshHeather C WhalleyPublished in: European psychiatry : the journal of the Association of European Psychiatrists (2020)
Findings describe small but robust associations between lifetime MDD and lower cognitive performance within a population-based sample. Overall effects were of modest effect size, suggesting limited clinical relevance. However, deficits within specific cognitive domains were more pronounced in relation to clinical characteristics, particularly severe psychosocial impairment.