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Cognitive functioning and lifetime major depressive disorder in UK Biobank.

Laura de NooijMathew A HarrisMark James AdamsToni-Kim ClarkeXueyi ShenSimon R CoxAndrew M McIntoshHeather C Whalley
Published in: European psychiatry : the journal of the Association of European Psychiatrists (2020)
Findings describe small but robust associations between lifetime MDD and lower cognitive performance within a population-based sample. Overall effects were of modest effect size, suggesting limited clinical relevance. However, deficits within specific cognitive domains were more pronounced in relation to clinical characteristics, particularly severe psychosocial impairment.
Keyphrases
  • major depressive disorder
  • bipolar disorder
  • traumatic brain injury
  • mental health
  • cross sectional
  • early onset
  • drug induced