Loss of KMT5C Promotes EGFR Inhibitor Resistance in NSCLC via LINC01510-Mediated Upregulation of MET.

Arpita S PalAlejandra AgredoNadia A LanmanJihye SonIkjot Singh SohalManvir BainsChennan Li Jenna Clingerman Kayla GatesAndrea L Kasinski

Published in: Cancer research (2022)

Dysregulation of the epigenetic modifier KMT5C can drive MET-mediated EGFRi resistance, implicating KMT5C loss as a putative biomarker of resistance and H4K20 methylation as a potential target in EGFRi-resistant lung cancer.

Keyphrases

small cell lung cancer
tyrosine kinase
dna methylation
cell proliferation
gene expression
long non coding rna
epidermal growth factor receptor
poor prognosis
signaling pathway
risk assessment
climate change
brain metastases