Clinical Significance of Signal Regulatory Protein Alpha (SIRPα) Expression in Hepatocellular Carcinoma.
Takahiro TomiyamaShinji ItohNorifumi IsedaKatsuya ToshidaYukiko Kosai-FujimotoTakahiro TominoTakeshi KuriharaYoshihiro NagaoKazutoyo MoritaNoboru HaradaYu-Chen LiuDaisuke OzakiKenichi KohashiYoshinao OdaMasaki MoriTomoharu YoshizumiPublished in: Annals of surgical oncology (2023)
High SIRPα expression in HCC indicates poor prognosis, possibly by inhibiting macrophage phagocytosis of tumor cells, promoting MDSC infiltration and inducing antitumor immunity. Treatment alternatives using SIRPα blockage should be considered in HCC as inhibiting macrophage antitumor immunity and MDSCs.