Kidney Transplantation in Times of Covid-19: Decision Analysis in the Canadian Context.
Ivan YanevMichael GagnonMatthew P ChengSteven ParaskevasDeepali KumarAlice DragomirRuth Sapir-PichhadzePublished in: Canadian journal of kidney health and disease (2021)
Our analyses suggest that short delays allowing pretransplant vaccination offered comparable to greater effectiveness than pursuing transplantation without delay, proposing transplant candidates should be prioritized to receive at least 2 doses of SARS-CoV-2 vaccine. Our scenario and sensitivity analyses suggest that caution must be exercised when declining DD offers in patients offered low risk DD and who are likely to incur significant delays in access to transplantation. While population-level herd immunity may decrease infection risk in transplant patients, more data are required on vaccine efficacy against SARS-CoV-2 and variants of concern in ESKD, and how efficacy may be modified by a third vaccine dose, maintenance immunosuppression and timing of induction and rejection therapies.
Keyphrases
- sars cov
- end stage renal disease
- ejection fraction
- newly diagnosed
- kidney transplantation
- coronavirus disease
- randomized controlled trial
- peritoneal dialysis
- systematic review
- prognostic factors
- respiratory syndrome coronavirus
- gene expression
- big data
- machine learning
- bone marrow
- cell therapy
- artificial intelligence