DHA and EPA Prevent Seizure and Depression-Like Behavior by Inhibiting Ferroptosis and Neuroinflammation via Different Mode-of-Actions in a Pentylenetetrazole-Induced Kindling Model in Mice.

Xueyan WangAiai XiaoYueqi YangYingcai ZhaoCheng Cheng WangYu-Ming WangJun HanZhengping WangMin- Wen

Published in: Molecular nutrition & food research (2022)

These results indicate that DHA and EPA can efficaciously alleviate PTZ-induced seizure and depressive-like behavior but with different efficiency and molecular mechanisms.

Keyphrases

high glucose
diabetic rats
cell death
drug induced
traumatic brain injury
depressive symptoms
signaling pathway
type diabetes
endothelial cells
adipose tissue
lipopolysaccharide induced
metabolic syndrome
cognitive impairment
blood brain barrier
sleep quality
high fat diet induced