Effect of Systemic Lupus and Immunosuppressives on COVID Vaccination Antibody Response.

SLE patients, regardless of background immunosuppressive therapy, had lower vaccine IgG levels than healthcare workers. Mycophenolate, tacrolimus, and belimumab significantly reduced IgG response to vaccination. Holding mycophenolate for one week improved vaccine efficacy, providing clinical benefit on vaccine response without leading to clinical flares.