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Molecular pathways driving disease-specific alterations of intestinal epithelial cells.

Rocío López-PosadasMarkus F NeurathImke Atreya
Published in: Cellular and molecular life sciences : CMLS (2016)
Due to the fact that chronic inflammation as well as tumorigenesis in the gut is crucially impacted by the fate of intestinal epithelial cells, our article provides a comprehensive overview of the composition, function, regulation and homeostasis of the gut epithelium. In particular, we focus on those aspects which were found to be altered in the context of inflammatory bowel diseases or colorectal cancer and also discuss potential molecular targets for a disease-specific therapeutic intervention.
Keyphrases
  • randomized controlled trial
  • oxidative stress