Integrative and Comprehensive Pancancer Analysis of Regulator of Chromatin Condensation 1 (RCC1).
Changwu WuYingjuan DuanSiming GongSonja KallendruschNikolas SchopowGeorg OsterhoffPublished in: International journal of molecular sciences (2021)
Regulator of Chromatin Condensation 1 (RCC1) is the only known guanine nucleotide exchange factor that acts on the Ras-like G protein Ran and plays a key role in cell cycle regulation. Although there is growing evidence to support the relationship between RCC1 and cancer, detailed pancancer analyses have not yet been performed. In this genome database study, based on The Cancer Genome Atlas, Genotype-Tissue Expression and Gene Expression Omnibus databases, the potential role of RCC1 in 33 tumors' entities was explored. The results show that RCC1 is highly expressed in most human malignant neoplasms in contrast to healthy tissues. RCC1 expression is closely related to the prognosis of a broad variety of tumor patients. Enrichment analysis showed that some tumor-related pathways such as "cell cycle" and "RNA transport" were involved in the functional mechanism of RCC1. In particular, the conducted analysis reveals the relation of RCC1 to multiple immune checkpoint genes and suggests that the regulation of RCC1 is closely related to tumor infiltration of cancer-associated fibroblasts and CD8+ T cells. Coherent data demonstrate the association of RCC1 with the tumor mutation burden and microsatellite instability in various tumors. These findings provide new insights into the role of RCC1 in oncogenesis and tumor immunology in various tumors and indicate its potential as marker for therapy prognosis and targeted treatment strategies.
Keyphrases
- renal cell carcinoma
- cell cycle
- gene expression
- cell proliferation
- genome wide
- poor prognosis
- transcription factor
- end stage renal disease
- newly diagnosed
- dna methylation
- dna damage
- endothelial cells
- magnetic resonance imaging
- stem cells
- ejection fraction
- binding protein
- mesenchymal stem cells
- risk factors
- computed tomography
- peritoneal dialysis
- risk assessment
- squamous cell
- replacement therapy
- nucleic acid
- long non coding rna
- contrast enhanced
- human health
- smoking cessation
- climate change