SOX9 Stem-Cell Factor: Clinical and Functional Relevance in Cancer.
Elsa Maribel AguilarMariana Avendaño-FélixErik Lizárraga-VerdugoMercedes BermúdezJosé Geovanni Romero-QuintanaRosalio Ramos PayánErika Ruiz-GarciaCesar López-CamarilloPublished in: Journal of oncology (2019)
Transcriptional and epigenetic embryonic programs can be reactivated in cancer cells. As result, a specific subset of undifferentiated cells with stem-cells properties emerges and drives tumorigenesis. Recent findings have shown that ectoderm- and endoderm-derived tissues continue expressing stem-cells related transcription factors of the SOX-family of proteins such as SOX2 and SOX9 which have been implicated in the presence of cancer stem-like cells (CSCs) in tumors. Currently, there is enough evidence suggesting an oncogenic role for SOX9 in different types of human cancers. This review provides a summary of the current knowledge about the involvement of SOX9 in development and progression of cancer. Understanding the functional roles of SOX9 and clinical relevance is crucial for developing novel treatments targeting CSCs in cancer.
Keyphrases
- stem cells
- transcription factor
- papillary thyroid
- squamous cell
- gene expression
- cell therapy
- squamous cell carcinoma
- lymph node metastasis
- dna binding
- childhood cancer
- induced apoptosis
- cancer therapy
- cell proliferation
- drug delivery
- mesenchymal stem cells
- heat shock
- genome wide identification
- pluripotent stem cells
- drug induced