Phenobarbital and midazolam suppress neonatal seizures in a noninvasive rat model of birth asphyxia, whereas bumetanide is ineffective.

Marie JohneKerstin RömermannPhilip Hampel Björn GailusWiebke TheilmannTommi Ala-KurikkaKai KailaWolfgang Löscher

Published in: Epilepsia (2020)

The data demonstrate that bumetanide does not increase the efficacy of phenobarbital in a model of birth asphyxia, which is consistent with the negative data of the recent human trial. The translational data obtained with the novel rat model of birth asphyxia indicate that it is a useful tool to evaluate novel treatments for neonatal seizures.

Keyphrases

electronic health record
big data
gestational age
clinical trial
study protocol
data analysis
machine learning
phase ii
deep learning
pregnancy outcomes
artificial intelligence
open label