Long non-coding RNA lung cancer-associated transcript-1 promotes glioblastoma progression by enhancing Hypoxia-inducible factor 1 alpha activity.
Haidong HuangHariti ShahJing HaoJianhong LinRichard A PraysonLiangqi XieShideng BaoAbhishek A ChakrabortyEckhard JankowskyJianjun ZhaoJennifer S YuPublished in: Neuro-oncology (2024)
A HIF1α-LUCAT1 axis forms a positive feedback loop to amplify HIF1α signaling in GSCs under hypoxia. LUCAT1 promotes GSC self-renewal and GBM tumor growth. LUCAT1 is a potential therapeutic target in GBM.