The roles of different Bacteroides uniformis strains in alleviating DSS-induced ulcerative colitis and related functional genes.
Chen WangHang GuoJunying BaiLeilei YuFengwei TianJianxin ZhaoHao ZhangJianxin ZhaoQixiao ZhaiPublished in: Food & function (2024)
Bacteroides is a common intestinal bacterium closely associated with host colitis. However, relevant studies have been focused on the genus level, which could not identify the major Bacteroides species associated with intestinal disease. Thus, we have evaluated the Bacteroides species structure in healthy people and mouse intestinal tracts and explored the change in major Bacteroides species during colitis development. The results demonstrated that B. uniformis with a high abundance in the intestinal tract of healthy people and mice may be a core species that contributes to colitis remission. The results of animal experiments reported that B. uniformis FNMHLBE1K1 (1K1) could alleviate the severity of colitis and enhance the expression of the tight junction protein occludin by regulating gut microbiota. Notably, the protective roles of 1K1 may be attributed to some specific genes. This study revealed that B. uniformis is a key microbe influencing the occurrence and development of colitis and it provides a scientific basis for screening the next generation of probiotics.
Keyphrases
- ulcerative colitis
- genetic diversity
- risk assessment
- poor prognosis
- escherichia coli
- blood brain barrier
- binding protein
- rheumatoid arthritis
- small molecule
- metabolic syndrome
- dna methylation
- oxidative stress
- high glucose
- systemic lupus erythematosus
- gene expression
- drug induced
- endothelial cells
- diabetic rats
- protein protein
- microbial community
- genome wide analysis
- antibiotic resistance genes
- wild type