miR-491 inhibits BGC-823 cell migration via targeting HMGA2.

Zhigang LiuYun LüQiuyu JiangYang YangChengxue DangRuifang Sun

Published in: The International journal of biological markers (2019)

Our results suggest that miR-491 suppressed cell proliferation and cell motility in gastric cancer by targeting HMGA2. Silencing HMGA2 produced a similar effect to miR-491 overexpression on cell proliferation and migration. miR-491/HMGA2 signaling may be a potential therapeutic target for gastric cancer patients with decreased miR-491 expression.

Keyphrases

cell proliferation
long non coding rna
long noncoding rna
cell cycle
poor prognosis
cell migration
single cell
pi k akt
cell therapy
staphylococcus aureus
cystic fibrosis
cancer therapy
pseudomonas aeruginosa
binding protein
biofilm formation