Localized Partitioning of Enantiomers in Solid Samples of Sulfoxides: Importance of Sampling Method in Determination of Enantiopurity.

Published in: The Journal of organic chemistry (2020)

Localized partitioning of amorphous enantioenriched aryl benzyl sulfoxides in the solid state can lead to substantial variation in enantiopurities, even for sulfoxides which do not show detectable levels of self-disproportionation of enantiomers (SDE) during chromatography on an achiral stationary phase. The importance of preparation of representative samples of enantioenriched sulfoxides for chiral HPLC to enable reproducible results is clear.

Keyphrases

solid state
capillary electrophoresis
mass spectrometry
solid phase extraction
liquid chromatography
high performance liquid chromatography
tandem mass spectrometry
molecularly imprinted
ms ms
simultaneous determination
high speed
cross sectional
high resolution
ionic liquid