Nerve growth factor orchestrates NGAL and matrix metalloproteinases activity to promote colorectal cancer metastasis.

Y LeiX HeH HuangY HeJ LanJ YangW LiuTao Zhang

Published in: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico (2021)

Our finding demonstrated that NGF increased NGAL expression to enhance MMPs activity to promoted colorectal cancer cell metastasis by TrkA-MAPK/Erk axis.

Keyphrases

growth factor
signaling pathway
pi k akt
poor prognosis
cell proliferation
binding protein