Inhibition of c-Fos expression attenuates IgE-mediated mast cell activation and allergic inflammation by counteracting an inhibitory AP1/Egr1/IL-4 axis.

Hui-Na WangKunmei JiLi-Na ZhangChu-Chu XieWei-Yong LiZhen-Fu ZhaoJia-Jie Chen

Published in: Journal of translational medicine (2021)

IgE binding can activate MCs via a c-Fos/Egr1/IL-4 axis. T-5224 suppresses MC activation in vitro and in vivo and thus represents a promising potential strategy for targeting MC activation to treat allergic diseases.

Keyphrases

poor prognosis
oxidative stress
transcription factor
binding protein
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risk assessment
climate change