Abnormal expression of the costimulatory molecule B7-H4 in placental chorionic villous and decidual basalis tissues of patients with preeclampsia and HELLP syndrome.
Liyan DuanBeatrix ReischAntonella IannacconeElina HadrovicYuqing WuRebekka VogtmannElke WinterhagerRainer KimmigAngela KöningerPawel MachAlexandra GellhausPublished in: American journal of reproductive immunology (New York, N.Y. : 1989) (2021)
B7-H4 was inversely expressed in placental chorionic villous and decidual basalis tissues of PE and HELLP patients. The increase in B7-H4 in the STB in PE and HELLP may lead to excessive apical expression and release of soluble B7-H4 in the maternal circulation. In contrast, the decrease in B7-H4 in decidual basalis tissues could be related to the decrease in invasion ability of the EVT in PE. Thus, the current results strongly suggest that B7-H4 is involved in the pathogenesis of PE and HELLP.
Keyphrases
- poor prognosis
- gene expression
- end stage renal disease
- ejection fraction
- newly diagnosed
- chronic kidney disease
- prognostic factors
- peritoneal dialysis
- pregnancy outcomes
- magnetic resonance imaging
- computed tomography
- long non coding rna
- weight gain
- case report
- patient reported outcomes
- body mass index
- contrast enhanced