Login / Signup

Abnormal expression of the costimulatory molecule B7-H4 in placental chorionic villous and decidual basalis tissues of patients with preeclampsia and HELLP syndrome.

Liyan DuanBeatrix ReischAntonella IannacconeElina HadrovicYuqing WuRebekka VogtmannElke WinterhagerRainer KimmigAngela KöningerPawel MachAlexandra Gellhaus
Published in: American journal of reproductive immunology (New York, N.Y. : 1989) (2021)
B7-H4 was inversely expressed in placental chorionic villous and decidual basalis tissues of PE and HELLP patients. The increase in B7-H4 in the STB in PE and HELLP may lead to excessive apical expression and release of soluble B7-H4 in the maternal circulation. In contrast, the decrease in B7-H4 in decidual basalis tissues could be related to the decrease in invasion ability of the EVT in PE. Thus, the current results strongly suggest that B7-H4 is involved in the pathogenesis of PE and HELLP.
Keyphrases