Effect of Maternal Immunization With 10-Valent Pneumococcus Conjugate Vaccine (PCV-10), 23-Valent Pneumococcus Polysaccharide Vaccine, or Placebo on the Immunogenicity of PCV-10 in Human Immunodeficiency Virus-Exposed Uninfected Infants: A Randomized Clinical Trial.
Marisa Márcia Mussi-PinhataShawn WardLauren LaimonStephen I PeltonJennifer CanniffAmanda GolnerFrederic BoneLassallete NewtonPetronella MuresanTerence FentonMichael J JohnsonEsau C JoãoBreno R SantosJose H PilottoRicardo H OliveiraJorge A PintoAndrea G B L Dal BóRegis KreitchmannNahida ChakhtouraGeraldo DuarteAdriana WeinbergPublished in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2022)
Administration of PCV-10 during pregnancy was associated with decreased antibody responses to PCV-10 and seroprotection rates in infants. Considering that PCV-10 and PPV-23 had similar immunogenicity in pregnant women with HIV and that administration of PPV-23 did not affect the immunogenicity of PCV-10 in infants, PPV-23 in pregnancy may be preferred over PCV-10.