Alcohol and its metabolites dysregulate cellular bioenergetics and induce oxidative and endoplasmic reticulum stress in primary human bronchial epithelial cells.
Lata KaphaliaMukund P SrinivasanBhupendra S KaphaliaWilliam J CalhounPublished in: Alcohol, clinical & experimental research (2024)
Findings of this study suggest that ethanol and its metabolites contribute to cytotoxicity, oxidative/ER stress, and dysregulation of cellular bioenergetics in hBECs. The attenuation of ethanol-induced ER/oxidative stress and mitochondrial respiration by an AMPKα agonist may reflect a potential for it to be developed as a therapeutic agent for chronic alcohol-associated lung disease.
Keyphrases
- endoplasmic reticulum stress
- oxidative stress
- induced apoptosis
- diabetic rats
- ms ms
- endothelial cells
- high glucose
- alcohol consumption
- dna damage
- drug induced
- skeletal muscle
- induced pluripotent stem cells
- ischemia reperfusion injury
- pluripotent stem cells
- estrogen receptor
- human health
- heat shock
- heat stress
- stress induced