Alterations in the inferior fronto-occipital fasciculus - a specific neural correlate of gender incongruence?
Jason O van HeesewijkMartijn D SteenwijkBaudewijntje P C KreukelsDick J VeltmanJulie BakkerSarah M BurkePublished in: Psychological medicine (2022)
Importantly, our results of lower FA (indexing less longitudinal organization, fiber coherence, and myelination) in the IFOF of gender-incongruent adolescents replicate prior findings in transgender adults, suggesting a salient neural correlate of gender incongruence. Findings highlight the complexity with which (pubertal) sex hormones impact white-matter development and add important insight into the neurobiological substrate associated with gender incongruence.