Brain amyloid burden, sleep, and 24-hour rest/activity rhythms: screening findings from the Anti-Amyloid Treatment in Asymptomatic Alzheimer's and Longitudinal Evaluation of Amyloid Risk and Neurodegeneration Studies.
Adam P SpiraVadim ZipunnikovRema RamanJiyoon ChoiJunrui DiJiawei BaiCynthia M CarlssonJacobo E MintzerGad A MarshallAnton P PorsteinssonRoy YaariSarah K WanigatungaJohn KimMark N WuPaul S AisenReisa A SperlingPaul B RosenbergPublished in: Sleep advances : a journal of the Sleep Research Society (2021)
Although we found no association of preclinical AD with standard actigraphic sleep or RAR metrics, a novel data-driven analytic method identified temporally "local" RAR alterations in preclinical AD.