Role of Renin-Angiotensin System in Acute Lung Injury Caused by Viral Infection.
Yan-Lei GaoYue DuChao ZhangCheng ChengHai-Yan YangYue-Fei JinGuang-Cai DuanShuai-Yin ChenPublished in: Infection and drug resistance (2020)
The renin-angiotensin system (RAS) is the most important regulatory system of electrolyte homeostasis and blood pressure and acts through angiotensin-converting enzyme (ACE)/angiotensin II (Ang II)/Ang II type 1 (AT1) receptor axis and angiotensin-converting enzyme 2 (ACE2)/angiotensin (1-7)/MAS receptor axis. RAS dysfunction is related to the occurrence and development of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) and causes a serious prognosis and even death. ALI/ARDS can be induced by various ways, one of which is viral infections, such as SARS-CoV, SARS-CoV-2, H5N1, H7N9, and EV71. This article reviews the specific mechanism on how RAS dysfunction affects ALI/ARDs caused by viral infections. SARS-CoV and SARS-CoV-2 enter the host cells by binding with ACE2. H5N1 and H7N9 avian influenza viruses reduce the ACE2 level in the body, and EV71 increases Ang II concentration. Treatment with angiotensin-converting enzyme inhibitor and angiotensin AT1 receptor blocker can alleviate ALI/ARDS symptoms. This review provides suggestions for the treatment of lung injury caused by viral infections.
Keyphrases
- angiotensin converting enzyme
- angiotensin ii
- sars cov
- acute respiratory distress syndrome
- extracorporeal membrane oxygenation
- mechanical ventilation
- vascular smooth muscle cells
- respiratory syndrome coronavirus
- blood pressure
- lipopolysaccharide induced
- induced apoptosis
- lps induced
- oxidative stress
- randomized controlled trial
- wild type
- type diabetes
- binding protein
- intensive care unit
- coronavirus disease
- cell proliferation
- sleep quality
- genetic diversity
- solid state