HIV-1 DNA decay is faster in children who initiate ART shortly after birth than later.
Kirsten A VeldsmanAnita Janse van RensburgShahieda IsaacsShalena NaidooBarbara LaughtonCarl LombardMark F CottonJohn W MellorsGert U van ZylPublished in: Journal of the International AIDS Society (2020)
These data suggest that ART initiation within the first week of life can reduce the persistence of long-lived infected cells. Delaying ART is associated with slower decay of infected cells.
Keyphrases
- hiv infected
- antiretroviral therapy
- induced apoptosis
- cell cycle arrest
- hiv positive
- human immunodeficiency virus
- young adults
- endoplasmic reticulum stress
- cell death
- hiv aids
- hepatitis c virus
- oxidative stress
- machine learning
- clinical trial
- circulating tumor
- electronic health record
- randomized controlled trial
- single molecule
- artificial intelligence
- gestational age