Ca2+ and innate immune pathways are activated and differentially expressed in childhood asthma phenotypes.
Andreas BöckKatja Landgraf-RaufVanessa VogelsangDiana SiemensOlivia Prazeres da CostaElisabeth KluckerErika von MutiusThorsten BuchUlrich MansmannBianca SchaubPublished in: Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology (2018)
Ca2+ regulation and innate immunity response pattern to viruses were activated in PBMCs of asthmatics. Asthma phenotypes were differentially characterized by distinct regulation of ATP2A3 and expression of innate immune receptors (FPR2, CLEC4E, IFIH1). These genes may present promising targets for future in-depth investigation with the long-term goal of more phenotype-specific therapeutic interventions in asthmatics.