Long term use of Proton Pump Inhibitor disrupts intestinal tight junction barrier and exaggerates experimental colitis.

Meghali NighotPei-Luan LiaoNathan Michael MorrisDennis MccarthyViszwapriya DharmaprakashInam Ullah KhanShannon DalessioKushal SahaAshwinkumar Subramaniam GanapathyAlexandra WangWei DingGregory YochumWalter KoltunPrashant NighotThomas Ma

Published in: Journal of Crohn's & colitis (2022)

Our results suggest that long term use of PPIs increases intestinal TJ permeability and exaggerates experimental colitis via increase in MLCK expression and activity.

Keyphrases

poor prognosis
blood brain barrier
ulcerative colitis
endothelial cells
binding protein
long non coding rna