Low-dose immune tolerance induction therapy in children of Arab descent with severe haemophilia A, high inhibitor titres and poor prognostic factors for immune tolerance induction treatment success.

Mohsen ElalfyIslam ElghamryHoda HassabOmar ElalfyNevine AndrawesMagdy El-Ekiaby

Published in: Haemophilia : the official journal of the World Federation of Hemophilia (2021)

A low-dose ITI therapy using a pdFVIII/VWF concentrate achieved at least partial tolerance in 80% of patients, and reduced annual bleeds in children with high inhibitor titres and at least one poor prognosis factor for ITI treatment success.

Keyphrases

prognostic factors
low dose
poor prognosis
young adults
high dose
end stage renal disease
ejection fraction
newly diagnosed
stem cells
combination therapy
cell therapy
chemotherapy induced