Valproate utilisation trends among women of childbearing potential in Ireland between 2014 and 2019: A drug utilisation study using interrupted time series.

John E HughesNiamh BuckleyYvonne LooneySinead CurranMaeve MulloolyKathleen Bennett

Published in: Pharmacoepidemiology and drug safety (2022)

Although no evidence of change was observed following the December 2014 intervention period, a significant decline in the prevalence ratio of valproate use was observed after the 2018 intervention, which may reflect the introduction of the most recent contraindication measures.

Keyphrases

randomized controlled trial
polycystic ovary syndrome
risk factors
emergency department
insulin resistance
drug induced
breast cancer risk