A Narrative Review about Autism Spectrum Disorders and Exclusion of Gluten and Casein from the Diet.
Pablo José González-DomenechFrancisco Diaz-AtienzaLuis Gutiérrez-RojasMaría Luisa Fernández-SotoCarmen Maria Gonzalez-DomenechPublished in: Nutrients (2022)
Our literature search focused on the gluten- and casein-free (GFCF) diet. The literature found shows the inexistence of enough scientific evidence to support a general recommendation of dietary intervention in children with ASD. Protocols and procedures for assessing risk and safety are also needed. Future lines: Prospective and controlled research studies with larger sample sizes and longer follow-up times are scarce and needed. In addition, studies considering an assessment of intestinal permeability, bacterial population, enzymatic, and inflammatory gastrointestinal activity are interesting to identify possible responders. Besides brain imaging techniques, genetic tests can also contribute as markers to evaluate the comorbidity of gastrointestinal symptoms.
Keyphrases
- autism spectrum disorder
- systematic review
- celiac disease
- weight loss
- physical activity
- case control
- randomized controlled trial
- high resolution
- intellectual disability
- young adults
- irritable bowel syndrome
- white matter
- genome wide
- endothelial cells
- hydrogen peroxide
- resting state
- dna methylation
- multiple sclerosis
- cerebral ischemia
- working memory
- fluorescence imaging