High Glucosylceramides and Low Anandamide Contribute to Sensory Loss and Pain in Parkinson's Disease.
Katharina Klatt-SchreinerLucie ValekJun-Suk KangAlexander KhlebtovskySandra TrautmannLisa HahnefeldYannick SchreiberRobert GurkeDominique ThomasAnnett Wilken-SchmitzSabine WickerGeorg AuburgerGerd GeisslingerJörn LötschWaltraud PfeilschifterRuth DjaldettiIrmgard TegederPublished in: Movement disorders : official journal of the Movement Disorder Society (2020)
Our data suggest that PD-associated sensory neuropathies and PD pain are in part caused by accumulations of glucosylceramides, raising the intriguing possibility of reducing PD pain and sensory loss by glucocerebrosidase substituting or refolding approaches. © 2020 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.