Various repair events following CRISPR/Cas9-based mutational correction of an infertility-related mutation in mouse embryos.

Bieke BekaertA BoelA RybouchkinG CosemansS DeclercqS M Chuva de Sousa LopesJ ParringtonD StoopP CouckeB MentenB Heindryckx

Published in: Journal of assisted reproduction and genetics (2024)

Our results suggest the occurrence of mosaicism and complex repair events after CRISPR/Cas9 DSB induction where chromosomal integrity is predominantly contained.

Keyphrases

crispr cas
genome editing
risk assessment
copy number
type diabetes
gene expression
adipose tissue
skeletal muscle
insulin resistance