White Matter Hyperintensity Volume and Poststroke Cognition: An Individual Patient Data Pooled Analysis of 9 Ischemic Stroke Cohort Studies.
Floor A S de KortMirthe CoenenNick A WeaverHugo J KuijfHugo P AbenHee Joon BaeRegis BordetGuido CammàChristopher Li Hsian ChenAnna DewenterMarco DueringRong FangRuben S van der GiessenOlivia K L HamiltonSaima HilalIrene M C Huenges WajerCheuk Ni KanJonguk KimBeom Joon KimSebastiaan KöhlerPaul L M de KortPeter J KoudstaalJae-Sung LimRenaud LopesVincent C T MokJulie StaalsNarayanaswamy VenketasubramanianCharlotte M VerhagenFrans Rochus Josef VerheyJoanna Marguerite WardlawXin XuKyung Ho YuJohannes Matthijs BiesbroekGeert Jan BiesselsPublished in: Stroke (2023)
In patients with ischemic stroke, increasing WMH volume is independently associated with worse cognitive functioning across all major domains, regardless of old ischemic lesions and infarct type.