HER2 regulates HIF-2α and drives an increased hypoxic response in breast cancer.

Edward J JarmanCarol WardArran K TurnbullCarlos Martinez-PerezJames MeehanChrysi XintaropoulouAndrew H SimsSimon P Langdon

Published in: Breast cancer research : BCR (2019)

This study suggests an important interplay between HER2 expression and HIF-2α in breast cancer and highlights the potential for HER2 to drive the expression of numerous hypoxia response genes in normoxia and hypoxia. Overall, these findings show the importance of understanding the regulation of HIF activity in a variety of breast cancer subtypes and points to the potential of targeting HIF-2α as a therapy for HER2-positive breast cancer.

Keyphrases

endothelial cells
positive breast cancer
poor prognosis
human health
binding protein
gene expression
dna methylation
cancer therapy