Lung Carcinoma Cells Secrete Exosomal MALAT1 to Inhibit Dendritic Cell Phagocytosis, Inflammatory Response, Costimulatory Molecule Expression and Promote Dendritic Cell Autophagy via AKT/mTOR Pathway.
Yanyan LiuZhucheng YinPing LuYifei MaBo LuoLanxin XiangWangli ZhangYu HeXinjun LiangPublished in: OncoTargets and therapy (2020)
Inhibition of MALAT1 expression in LLC-derived exosomes promoted DC function and T cell proliferation and suppressed DC autophagy and T cell differentiation, suggesting that MALAT1 inhibition may be a potential strategy for the clinical treatment of lung cancer.
Keyphrases
- dendritic cells
- cell proliferation
- poor prognosis
- inflammatory response
- signaling pathway
- regulatory t cells
- cell death
- immune response
- endoplasmic reticulum stress
- oxidative stress
- binding protein
- stem cells
- mesenchymal stem cells
- cell cycle
- long non coding rna
- risk assessment
- toll like receptor
- bone marrow
- replacement therapy