Molecular Phenotypes of ARDS in the ROSE Trial have Differential Outcomes and Gene Expression Patterns That Differ at Baseline and Longitudinally Over Time.
Pratik SinhaLucile P A NeytonAartik SarmaNelson WuChayse JonesHanjing ZhuoKathleen D LiuEstella Sanchez GuerreroRajani GhaleChristina LoveEran MickKevin L DelucchiCharles R LangelierB Taylor ThompsonMichael A MatthayCarolyn S Calfeenull nullPublished in: American journal of respiratory and critical care medicine (2024)
The Hyperinflammatory and Hypoinflammatory phenotypes have different clinical, protein, and dynamic transcriptional characteristics. These findings support the clinical and biological potential of molecular phenotypes to advance precision care in ARDS.
Keyphrases
- gene expression
- acute respiratory distress syndrome
- healthcare
- extracorporeal membrane oxygenation
- mechanical ventilation
- dna methylation
- clinical trial
- palliative care
- study protocol
- transcription factor
- randomized controlled trial
- type diabetes
- quality improvement
- metabolic syndrome
- small molecule
- adipose tissue
- phase iii
- pain management
- skeletal muscle
- insulin resistance
- amino acid
- glycemic control
- double blind