Administration and effects of beta blockers and oxandrolone in severely burned adults: a post hoc analysis of the RE-ENERGIZE trial.
Gabriel HundeshagenElisabeth BlearsViktoria MertinAndrew G DayAlen PalackicChristian TapkingValentin HaugUlrich KneserBjörn BliesenerAdriana C PanayiAriel AballayFrancois DepretChristian StoppeDaren K HeylandPublished in: Burns & trauma (2024)
The use of OX, BB and BBOX is common within the adult burn patient population, with its use varying considerably across sites worldwide. Our findings found mixed associations between outcomes and the use of BB and OX in adult burn patients, with lower acute and 6-month-mortality with BB and longer times to discharge with OX. Further research into these pharmacological modulators of the pathophysiological response to severe burn injury is indicated.
Keyphrases
- growth factor
- wound healing
- recombinant human
- liver failure
- low density lipoprotein
- clinical trial
- small molecule
- study protocol
- cardiovascular events
- childhood cancer
- respiratory failure
- phase iii
- randomized controlled trial
- phase ii
- type diabetes
- skeletal muscle
- insulin resistance
- metabolic syndrome
- coronary artery disease
- extracorporeal membrane oxygenation
- weight loss
- adipose tissue
- acute respiratory distress syndrome