Trial of Botulinum Toxin for Isolated or Essential Head Tremor.
Ana MarquesBruno PereiraMarion Simonetta-MoreauGiovanni CastelnovoMarie De VerdalFrédérique FluchèreChloé LaurencinBertrand DegosMélissa TirAlexandre KreislerGeneviève Blanchet-FourcadeDominique GuehlOlivier ColinAurelia PoujoisSophie SanglaLaurent TatuPhilippe DerostDominique GayraudChristine TranchantDavid AmarantiniDavid DevosOlivier RascolJean-Christophe CorvolFranck DurifIsabelle Rieunull nullPublished in: The New England journal of medicine (2023)
Injection of botulinum toxin into each splenius capitis muscle on day 0 and during week 12 was more effective than placebo in reducing the severity of isolated or essential head tremor at 18 weeks but not at 24 weeks, when the effects of injection might be expected to wane, and was associated with adverse events. (Funded by the French Ministry of Health; Btx-HT ClinicalTrials.gov number, NCT02555982.).