Myocardial sodium-glucose cotransporter 2 expression and cardiac remodelling in patients with severe aortic stenosis: The BIO-AS study.
Lucia ScisciolaPasquale PaolissoMarta BelmonteEmanuele GallinoroLeen DelrueFatemeh TaktazRosaria Anna FontanellaIvan DegrieckAda PesapaneFilip CasselmanArmando PuocciMartina FranzeseFrank Van PraetMichele TorellaRaffaele MarfellaMarisa De FeoJozef BartunekGiuseppe PaolissoEmanuele BarbatoMichelangela BarbieriMarc VanderheydenPublished in: European journal of heart failure (2024)
In patients with LF-LG AS, SGLT2 gene and protein were hyper-expressed in cardiomyocytes and associated with myocardial fibrosis, inflammation, and oxidative stress.
Keyphrases
- left ventricular
- aortic stenosis
- oxidative stress
- aortic valve replacement
- transcatheter aortic valve replacement
- ejection fraction
- transcatheter aortic valve implantation
- aortic valve
- poor prognosis
- heart failure
- binding protein
- dna damage
- genome wide
- coronary artery disease
- early onset
- copy number
- ischemia reperfusion injury
- protein protein
- small molecule
- drug induced
- long non coding rna
- amino acid
- gene expression
- liver fibrosis
- endothelial cells
- heat shock protein
- high glucose