Loss of Endothelial Cytochrome P450 Reductase Induces Vascular Dysfunction in Mice.
Pedro Felipe MalacarneCorina RatiuAnna Gajos-DrausNiklas MüllerMelina LopezBeatrice Pflüger-MüllerXinxin DingTimothy WarwickJames OoMauro SiragusaCarlo AngioniStefan GüntherAndreas WeigertGerd GeißlingerDieter LütjohannWolf-Hagen SchunckIngrid FlemingRalf P BrandesFlávia RezendePublished in: Hypertension (Dallas, Tex. : 1979) (2022)
POR expression in endothelial cells maintains eNOS activity and its loss results in an overactivation of the vasoconstrictor prostanoid system. Through these mechanisms, loss of endothelial POR induces vascular dysfunction and hypertension.