Effectiveness of Nicotinamide Phosphoribosyltransferase/Pre-B Cell Colony-enhancing Factor/Visfatin in preventing High Glucose-induced Neurotoxicity in an In-vitro Model of Diabetic Neuropathy.
Sarvin JahanbaniMehdi KhaksariFatemeh Sadat BitarafMajid RahmatiKobra ForoughiAsghar ShayanniaPublished in: Basic and clinical neuroscience (2023)
Diabetes mellitus is a metabolic disorder characterized by hyperglycemia resulting from a failure in insulin secretion, insulin action, or both. Visfatin (Nampt/PBEF) has insulin-mimetic effects. So far, no study has assessed its effects on diabetic neuropathy. Therefore, we examined the neuroprotective effects of visfatin on cell line 12 (PC12) against glucose-induced neurotoxicity. Based on the results, it was concluded that the Nampt/PBEF/visfatin can significantly reduce neural damage caused by production of reactive oxygen species and apoptosis of diabetic PC12 cell.
Keyphrases
- high glucose
- type diabetes
- endothelial cells
- diabetic rats
- oxidative stress
- reactive oxygen species
- glycemic control
- wound healing
- randomized controlled trial
- systematic review
- cell death
- endoplasmic reticulum stress
- stem cells
- bone marrow
- metabolic syndrome
- adipose tissue
- blood pressure
- cell cycle arrest
- blood brain barrier
- cell proliferation
- cerebral ischemia