Therapeutic Potential of a Self-Assembling Peptide Hydrogel to Treat Colonic Injuries Associated with Inflammatory Bowel Disease.

Toshihiro ArakiKeiichi MitsuyamaHiroshi YamasakiMasaru MoritaKozo TsurutaAtsushi MoriTetsuhiro YoshimuraShuhei FukunagaKotaro KuwakiShinichiro YoshiokaHidetoshi TakedatsuTatsuyuki KakumaJun AkibaTakuji Torimura

Published in: Journal of Crohn's & colitis (2022)

SAPH application effectively suppressed colonic injury, downregulated inflammatory cytokine expression, and upregulated wound healing-related factor expression in the rat model; thus, it may represent a promising therapeutic strategy for IBD-related colonic ulcers.

Keyphrases

ulcerative colitis
wound healing
poor prognosis
binding protein
oxidative stress
long non coding rna
hyaluronic acid