Distinct lipid profiles predict improved glycemic control in obese, nondiabetic patients after a low-caloric diet intervention: the Diet, Obesity and Genes randomized trial.
Armand ValsesiaWim Hm SarisArne AstrupJörg HagerMojgan MasoodiPublished in: The American journal of clinical nutrition (2016)
In this study, we report a lipid signature of LCD success (for weight and glycemic outcome) in obese, nondiabetic patients. Lipid changes during an 8-wk LCD allowed us to predict insulin-resistant patients after 6 mo of weight maintenance. The determination of the lipid composition during an LCD enables the identification of nonresponders and may help clinicians manage metabolic outcomes with further intervention, thereby improving the long-term outcome and preventing T2D. This trial was registered at clinicaltrials.gov as NCT00390637.
Keyphrases
- weight loss
- type diabetes
- end stage renal disease
- glycemic control
- newly diagnosed
- ejection fraction
- metabolic syndrome
- physical activity
- chronic kidney disease
- peritoneal dialysis
- body mass index
- adipose tissue
- insulin resistance
- gene expression
- prognostic factors
- fatty acid
- weight gain
- patient reported outcomes
- dna methylation
- genome wide
- phase iii
- blood glucose
- body weight
- high fat diet induced
- bioinformatics analysis