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Olfactomedin-4 + neutrophils exacerbate intestinal epithelial damage and worsen host survival after Clostridioides difficile infection.

A HuberShinsmon JoseA KassamK N WeghornMargaret V Powers-FletcherD SharmaA MukherjeeA MathewN KulkarniS ChandramouliMatthew N AlderRajat Madan
Published in: bioRxiv : the preprint server for biology (2023)
Utilizing single-cell transcriptomics, IEC-epithelial co-cultures, and pre-clinical models of CDI, we have identified a subset of neutrophils that are marked by OLFM4 expression as pathogenic determinants of IEC barrier damage after CDI.
Keyphrases
  • single cell
  • rna seq
  • clostridium difficile
  • oxidative stress
  • poor prognosis
  • high throughput