Olfactomedin-4 + neutrophils exacerbate intestinal epithelial damage and worsen host survival after Clostridioides difficile infection.
A HuberShinsmon JoseA KassamK N WeghornMargaret V Powers-FletcherD SharmaA MukherjeeA MathewN KulkarniS ChandramouliMatthew N AlderRajat MadanPublished in: bioRxiv : the preprint server for biology (2023)
Utilizing single-cell transcriptomics, IEC-epithelial co-cultures, and pre-clinical models of CDI, we have identified a subset of neutrophils that are marked by OLFM4 expression as pathogenic determinants of IEC barrier damage after CDI.