APOE epsilon variants and composite risk of dementia, disability, and death in the health and retirement study.
Santiago Clocchiatti-TuozzoNatalia SzejkoCyprien A RivierDaniela RenedoShufan HuoKevin N ShethThomas M GillGuido J FalconePublished in: Journal of the American Geriatrics Society (2024)
APOE ε variants are linked to the risk of dementia, disability, and death in older adults. By examining these variants in clinical trials, we can better elucidate how they might alter the effectiveness of tested interventions. Importantly, this genetic information could help identify participants who may have greater absolute benefit from such interventions.
Keyphrases
- copy number
- mild cognitive impairment
- cognitive decline
- physical activity
- clinical trial
- multiple sclerosis
- cognitive impairment
- randomized controlled trial
- public health
- healthcare
- health information
- genome wide
- systematic review
- mental health
- dna methylation
- metabolic syndrome
- type diabetes
- risk assessment
- skeletal muscle
- insulin resistance
- study protocol
- health promotion