TOX promotes follicular helper T cell differentiation in patients with primary Sjögren's syndrome.
Suying LiuYanlei YangLiuting ZengLi WangChengmei HeZhilei ChenJinlei SunTaibiao LyuMu WangHua ChenFengchun ZhangPublished in: Rheumatology (Oxford, England) (2022)
Our data suggest that TOX in pSS naive CD4+ T cells are upregulated which facilitates Tfh cell differentiation. Mechanistically, interferon-α induces TOX overexpression in naive CD4+ T cells through JAK-STAT1 signaling and TOX regulates BCL6 expression. Therefore, JAK-STAT1 signaling and TOX might be potential therapeutic targets in pSS.