TOX promotes follicular helper T cell differentiation in patients with primary Sjögren's syndrome.

Suying LiuYanlei YangLiuting ZengLi WangChengmei HeZhilei ChenJinlei SunTaibiao LyuMu WangHua ChenFengchun Zhang

Published in: Rheumatology (Oxford, England) (2022)

Our data suggest that TOX in pSS naive CD4+ T cells are upregulated which facilitates Tfh cell differentiation. Mechanistically, interferon-α induces TOX overexpression in naive CD4+ T cells through JAK-STAT1 signaling and TOX regulates BCL6 expression. Therefore, JAK-STAT1 signaling and TOX might be potential therapeutic targets in pSS.

Keyphrases

hiv infected
dendritic cells
poor prognosis
cell proliferation
regulatory t cells
transcription factor
big data
immune response
long non coding rna
climate change
antiretroviral therapy