Illuminating links between cis-regulators and trans-acting variants in the human prefrontal cortex.

Shuang LiuHyejung WonDeclan ClarkeNana MatobaSaniya KhullarYudi MuDaifeng Wang Mark B Gerstein

Published in: Genome medicine (2022)

We demonstrate that the transcriptional architecture of the human brain is orchestrated by both cis- and trans-regulatory variants and found that trans-eQTLs provide insights into brain-disease biology.

Keyphrases

prefrontal cortex
transcription factor
copy number
endothelial cells
gene expression
resting state
induced pluripotent stem cells
multiple sclerosis
oxidative stress
pluripotent stem cells
functional connectivity
heat shock
subarachnoid hemorrhage
heat stress