Novel Mouse Model of Myocardial Infarction, Plaque Rupture, and Stroke Shows Improved Survival With Myeloperoxidase Inhibition.
Sohel ShamsuzzamanRebecca A DeatonAnita SalamonHeather DoviakVlad SerbuleaVictoria M MilosekMegan A EvansSantosh KarnewarSubhi SaibabaGabriel F AlencarLaura S ShankmanKenneth WalshStefan BekiranovOlivier KocherMonty KriegerBengt KullMarie PerssonErik MichaëlssonNils BergenhemSepideh Heydarkhan-HagvallGary K OwensPublished in: Circulation (2024)
mice more closely replicate late-stage clinical events of advanced human atherosclerotic disease than previous models and can be used to identify and test potential new therapeutic agents to prevent major adverse cardiac events.