Predicting sporadic Alzheimer's disease progression via inherited Alzheimer's disease-informed machine-learning.

Nicolai FranzmeierNikolaos KoutsoulerisTammie BenzingerAlison GoateCeleste M KarchAnne M FaganEric McDadeMarco DueringMartin DichgansJohannes LevinBrian A GordonYen Ying LimColin L MastersMartin RossorNick C FoxAntoinette O'ConnorJasmeer ChhatwalStephen SallowayAdrian DanekJason HassenstabPeter R SchofieldJohn C MorrisRandall J Batemannull nullnull nullMichael Ewers

Published in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2020)

Our independently validated machine-learning model predicted cognitive decline in sporadic prodromal AD and may substantially reduce sample size needed in clinical trials in AD.

Keyphrases

cognitive decline
machine learning
mild cognitive impairment
clinical trial
late onset
amyotrophic lateral sclerosis
artificial intelligence
big data
deep learning
parkinson disease
randomized controlled trial
phase ii
open label
study protocol
deep brain stimulation