Treatment of Chronic Spinal Cord Injury in Dogs Using Amniotic Membrane-Derived Stem Cells: Preliminary Results.
Jéssica Rodrigues OrlandinIngrid da Silva GomesShamira de Fátima Sallum LeandroArtur Fuertes CagnimJuliana Barbosa CasalsAdriano Bonfim CarregaroSilvio Henrique FreitasLuciana Cristina MachadoMaria Cristina Reis CastiglioniAna Liz Garcia AlvesVânia Maria de Vasconcelos MachadoCarlos Eduardo AmbrosioPublished in: Stem cells and cloning : advances and applications (2021)
The protocol of preclinical trial showed the association with decompressive surgery and cell transplantation in dogs with thoracolumbar IVDD proved feasible, and it was possible to observe neurological improvement after treatment. No tissue improvement through MRI was found. The double-blind test guaranteed reliability of the evaluations and results obtained that, even with a small sample size, generated satisfactory results for the animals and owners.
Keyphrases
- cell therapy
- stem cells
- spinal cord injury
- clinical trial
- phase iii
- study protocol
- double blind
- minimally invasive
- phase ii
- magnetic resonance imaging
- randomized controlled trial
- coronary artery bypass
- single cell
- contrast enhanced
- neuropathic pain
- open label
- mesenchymal stem cells
- combination therapy
- magnetic resonance
- severe traumatic brain injury