RAS status and neoadjuvant chemotherapy impact CD8+ cells and tumor HLA class I expression in liver metastatic colorectal cancer.

Fanny LedysQuentin KlopfensteinCaroline TruntzerLaurent ArnouldJulie VincentLeila BengrineRomain RemarkRomain BoidotSylvain LadoireFrancois GhiringhelliValentin Derangere

Published in: Journal for immunotherapy of cancer (2018)

While CD8 infiltrate and HLA expression appear to be prognostic for mCRC, CD8 and PD-L1 infiltrate are enhanced by neoadjuvant chemotherapy in mCRC under RAS status dependence.

Keyphrases

neoadjuvant chemotherapy
locally advanced
lymph node
poor prognosis
sentinel lymph node
metastatic colorectal cancer
induced apoptosis
rectal cancer
nk cells
squamous cell carcinoma
radiation therapy
binding protein
cell cycle arrest
oxidative stress
cell proliferation